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Cayman Chemical ANTIBODY PHA-543613 10mg
Supplier: Cayman Chemical 4222210 MG
An agonist of α7 nAChRs; selective for α7 nAChRs over α4β2-, α4β4-, α3β2-, or α3β4 subunit-containing nAChRs and 5-HT3 (EC50s = 0.03, >100, >50, >100, >100, and 11 µM, respectively, in calcium mobilization assays); prevents decreases in the number of retinal ganglion cells in a rat model of glaucoma when applied topically; improves sensorimotor deficits and brain edema in a mouse model of intracerebral hemorrhage; increases the time spent with the novel object in the novel object recognition test and reverses amphetamine-induced auditory gating deficits in rats at 1 mg/kg; reduces food intake and body weight in rats
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