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Cayman Chemical PKI-402, Purity: ≥98%, CAS: 1173204-81-3, 25 mg
SDP

Catalog No. 502940305
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A dual inhibitor of PI3K and mTOR (IC50s = 1.4, 9.2, and 1.7 nM for PI3Kα, PI3Kγ, and mTOR, respectively); reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively); inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 = 5 nM); reduces intratumor phosphorylation of Akt and tumor growth in an MDA-MB-361 mouse xenograft model at 25, 50, and 100 mg/kg; inhibits tumor growth in U87MG glioma and A549 lung cancer mouse xenograft models

Catalog No. 50-294-0305 Supplier Cayman Chemical Supplier No. 2766425 MG
May include imposed supplier surcharges.
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A dual inhibitor of PI3K and mTOR (IC50s = 1.4, 9.2, and 1.7 nM for PI3Kα, PI3Kγ, and mTOR, respectively); reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively); inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 = 5 nM); reduces intratumor phosphorylation of Akt and tumor growth in an MDA-MB-361 mouse xenograft model at 25, 50, and 100 mg/kg; inhibits tumor growth in U87MG glioma and A549 lung cancer mouse xenograft models

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