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Cayman Chemical Probenecid, Purity: ≥98%, CAS: 57-66-9, 10 g
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Catalog No. 502973155
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An inhibitor of OATs and MRP1 and an agonist of TRPV2; inhibits OAT1, OAT3, and OAT6 (Kis = 6.3, 9.0, and 8.4 µM, respectively), as well as OAT2 (IC50 = 0.67 µM); selective for OATs over OCT1 and OCT2 (IC50s = 1,600 and 1,700 µM, respectively); decreases Fas antibody-induced GSH efflux and staurosporine-induced efflux of the MRP1 substrate calcein in Jurkat cells and decreases apoptotic progression at 7 mM; an agonist of TRPV2 (EC50 = 31.9 µM); induces nociceptive behavior in mouse models of carrageenan- or complete Freund’s adjuvant-induced inflammatory pain at 20 mM in drinking water in combination with doses of carrageenan or CFA that do not provoke pain responses alone

Catalog No. 50-297-3155 Supplier Cayman Chemical Supplier No. 1498110 G
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An inhibitor of OATs and MRP1 and an agonist of TRPV2; inhibits OAT1, OAT3, and OAT6 (Kis = 6.3, 9.0, and 8.4 µM, respectively), as well as OAT2 (IC50 = 0.67 µM); selective for OATs over OCT1 and OCT2 (IC50s = 1,600 and 1,700 µM, respectively); decreases Fas antibody-induced GSH efflux and staurosporine-induced efflux of the MRP1 substrate calcein in Jurkat cells and decreases apoptotic progression at 7 mM; an agonist of TRPV2 (EC50 = 31.9 µM); induces nociceptive behavior in mouse models of carrageenan- or complete Freund’s adjuvant-induced inflammatory pain at 20 mM in drinking water in combination with doses of carrageenan or CFA that do not provoke pain responses alone

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