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Cayman Chemical Roslin-2, Purity: ≥98%, CAS: 29574-21-8, 1 mg
SDP

Catalog No. 502987711
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A reactivator of p53; impairs the interaction between FAK and p53 and restores p53 transcriptional activity at 111, 333, and 1000 µM; reverses FAK-mediated suppression of the expression of p53-dependent p21, MDM2, and Bax in wild-type p53 HCT116 colon and MCF-7 breast cancer cells, but not in p53 mutant SW620 colon cancer cells at 1-50 µM; potentiates the pro-apoptotic effect of doxorubicin and 5-fluorouracil in p53+/+, but not p53-/-, HCT116 cells at 10 µM; reduces tumor growth and activates p21 in p53+/+, but not p53-/- tumors, in HCT116 mouse xenograft models at 60 mg/kg

Catalog No. 50-298-7711 Supplier Cayman Chemical Supplier No. 219851 MG
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A reactivator of p53; impairs the interaction between FAK and p53 and restores p53 transcriptional activity at 111, 333, and 1000 µM; reverses FAK-mediated suppression of the expression of p53-dependent p21, MDM2, and Bax in wild-type p53 HCT116 colon and MCF-7 breast cancer cells, but not in p53 mutant SW620 colon cancer cells at 1-50 µM; potentiates the pro-apoptotic effect of doxorubicin and 5-fluorouracil in p53+/+, but not p53-/-, HCT116 cells at 10 µM; reduces tumor growth and activates p21 in p53+/+, but not p53-/- tumors, in HCT116 mouse xenograft models at 60 mg/kg

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