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Cayman Chemical ANTIBODY SB-242235 25mg
Supplier: Cayman Chemical 3511725 MG
A p38α MAPK inhibitor (IC50 = 0.019 µM); selective for p38α MAPK over a panel of 10 kinases, including ERK2, JNK1, EGFR, and C-RAF (IC50s = >10 µM for all); inhibits IL-1α-induced production of NO in bovine articular cartilage explants (IC50 = ~1 µM); inhibits increases in epidermal COX-2 levels and erythema in mice exposed to UVB irradiation at 100 mg/kg; reduces paw edema in a rat model of adjuvant-induced arthritis at 10, 30, and 60 mg/kg
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