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Cayman Chemical SH-4-54, Purity: ≥98%, CAS: 1456632-40-8, 5 mg
SDP

Catalog No. 502932816
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A STAT3 inhibitor (IC50 = 4.7 μM for STAT3 homodimer DNA binding activity); selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5; decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells; inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively); inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models at 3 mg/kg per day

Catalog No. 50-293-2816 Supplier Cayman Chemical Supplier No. 259825 MG
May include imposed supplier surcharges.
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A STAT3 inhibitor (IC50 = 4.7 μM for STAT3 homodimer DNA binding activity); selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5; decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells; inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively); inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models at 3 mg/kg per day

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