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Cayman Chemical SIB 1757, Purity: ≥95%, CAS: 31993-01-8, 25 mg
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Catalog No. 502909530
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An antagonist of mGluR5a; selectively inhibits glutamate-induced calcium release and quisqualate-induced phosphoinositol accumulation in fibroblasts expressing human mGluR5a (IC50s = 0.37 and 3.1 µM, respectively) over mGluR1b-expressing fibroblasts (IC50s = >100 µM for both); selective for mGluR5a over mGluR2, mGluR3, mGluR4a, mGluR6, mGluR7b, mGluR8 (IC50s = >100 µM for all) as well as AMPA, kainate, and NMDA receptors (IC50s = >30 µM for all); inhibits (S)-3,5-DHPG-induced phosphoinositol accumulation in isolated neonatal rat hippocampus and striatum (IC50s = 5.2 and 10.1 µM, respectively); intrathecal administration increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain at 0.01 µg/animal

Catalog No. 50-290-9530 Supplier Cayman Chemical Supplier No. 3544225 MG
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An antagonist of mGluR5a; selectively inhibits glutamate-induced calcium release and quisqualate-induced phosphoinositol accumulation in fibroblasts expressing human mGluR5a (IC50s = 0.37 and 3.1 µM, respectively) over mGluR1b-expressing fibroblasts (IC50s = >100 µM for both); selective for mGluR5a over mGluR2, mGluR3, mGluR4a, mGluR6, mGluR7b, mGluR8 (IC50s = >100 µM for all) as well as AMPA, kainate, and NMDA receptors (IC50s = >30 µM for all); inhibits (S)-3,5-DHPG-induced phosphoinositol accumulation in isolated neonatal rat hippocampus and striatum (IC50s = 5.2 and 10.1 µM, respectively); intrathecal administration increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain at 0.01 µg/animal

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