Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 502916768

Cayman Chemical Siremadlin, Purity: ≥98%, CAS: 1448867-41-1, 1 mg
SDP

Catalog No. 502916768
Encompass_Preferred

A MDM2-p53 protein-protein interaction inhibitor (IC50 = 0.21 nM); selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53, YAP1-TEAD4, PCSK9-LDLR, and Bcl-2-Bak interactions in TR-FRET assays (IC50s = 3.3, >150, >50, and >50 µM, respectively); inhibits the growth of SJSA-1 cells (GI50 = 38 nM); induces apoptosis in SJSA-1 cells at 100 nM; induces tumor regression and prevents tumor regrowth in an SJSA-1 rat xenograft model and an HSAX2655 PDX rat liposarcoma model at 27 mg/kg

Catalog No. 50-291-6768 Supplier Cayman Chemical Supplier No. 385161 MG
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

A MDM2-p53 protein-protein interaction inhibitor (IC50 = 0.21 nM); selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53, YAP1-TEAD4, PCSK9-LDLR, and Bcl-2-Bak interactions in TR-FRET assays (IC50s = 3.3, >150, >50, and >50 µM, respectively); inhibits the growth of SJSA-1 cells (GI50 = 38 nM); induces apoptosis in SJSA-1 cells at 100 nM; induces tumor regression and prevents tumor regrowth in an SJSA-1 rat xenograft model and an HSAX2655 PDX rat liposarcoma model at 27 mg/kg

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.