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Cayman Chemical SPA70, Purity: ≥90%, CAS: 931314-31-7, 25 mg
SDP

Catalog No. 502947319
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A PXR antagonist (IC50 = 0.51 µM); selective for PXR over 10 additional nuclear receptors at >5 µM, as well as over a panel of 384 kinases at 10 µM; inhibits rifampicin-induced PXR activation from 0.1-10 µM; inhibits rifampicin-induced CYP3A4 activity in primary human hepatocytes; inhibits PXR agonist-induced CYP3A4-mediated metabolism of midazolam and paclitaxel in hPXR-tg mice at 200 mg/kg

Catalog No. 50-294-7319 Supplier Cayman Chemical Supplier No. 3449025 MG
May include imposed supplier surcharges.
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A PXR antagonist (IC50 = 0.51 µM); selective for PXR over 10 additional nuclear receptors at >5 µM, as well as over a panel of 384 kinases at 10 µM; inhibits rifampicin-induced PXR activation from 0.1-10 µM; inhibits rifampicin-induced CYP3A4 activity in primary human hepatocytes; inhibits PXR agonist-induced CYP3A4-mediated metabolism of midazolam and paclitaxel in hPXR-tg mice at 200 mg/kg

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