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Cayman Chemical ANTIBODY Sparsentn 25mg
Supplier: Cayman Chemical 3342925 MG
A dual antagonist of AT1 and ETA (Kis = 0.8 and 9.3 nM, respectively, for the human receptors); selective for these receptors over AT2 and ETB receptors (Kis = >10 µM for both); inhibits angiotensin II-induced pressor responses in conscious normotensive rats (ED50 = 3.6 µmol/kg, p.o); reduces mean arterial pressure in spontaneously hypertensive rats at 10, 30, or 100 µmol/kg per day, p.o.; reduces albuminuria and inhibits development of glomerulosclerosis in the gddY mouse model of IgA nephropathy when administered in the diet at 1,800 ppm
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