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Cayman Chemical SR 12343, Purity: ≥98%, CAS: 2055101-86-3, 10 mg
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Catalog No. 502989791
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An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; selectively disrupts the association of NEMO/IKKγ with IKKβ over TRAF2, IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at 25-150 µM; inhibits TNF-α-induced NF-κB activation in a reporter assay; reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia at 10 mg/kg; improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg

Catalog No. 50-298-9791 Supplier Cayman Chemical Supplier No. 3103110 MG
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An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; selectively disrupts the association of NEMO/IKKγ with IKKβ over TRAF2, IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at 25-150 µM; inhibits TNF-α-induced NF-κB activation in a reporter assay; reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia at 10 mg/kg; improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg

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