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Cayman Chemical ANTIBODY TDI-11861 500ug
Supplier: Cayman Chemical 39922500 UG
A soluble adenylyl cyclase inhibitor (IC50 = 3.3 nM); selective for sAC over AC1, AC2, AC5, AC8, and AC9 at 100 nM, a panel of 322 kinases (IC50s = >1,000 nM for all), and 46 other targets, including GPCRs, nuclear receptors, and ion channels (RC50s = >9 µM for all); inhibits capacitation-induced cAMP accumulation in isolated mouse and human sperm at 5 µM; reduces sodium bicarbonate-induced increases in mouse and human sperm beat frequency at 5 µM; induces temporary infertility in male mice without affecting mating behavior after a single dose of 50 mg/kg
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