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Cayman Chemical ANTIBODY ThIo-TEPA 250mg
Supplier: Cayman Chemical 23745250 MG
An alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells); alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage; crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand cross-links in L1210 and MCF-7 cancer cells in vitro; reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells; decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice
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