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Cayman Chemical XL335, Purity: ≥98%, CAS: 629664-81-9, 5 mg
SDP

Catalog No. 502993850
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A potent and selective FXR agonist (EC50 = 4 nM in CV-1 cells transfected with human FXR); selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 μM; induces a 20-, 13-, and 2-fold increase in mRNA expression for IBABP, BSEP, and SHP, respectively, at a concentration of 1 μM; reduces plasma cholesterol and triglycerides and the area of pre-atherosclerotic lesions in LDLR-/- mice fed a Western diet; decreases hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis

Catalog No. 50-299-3850 Supplier Cayman Chemical Supplier No. 233505 MG
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A potent and selective FXR agonist (EC50 = 4 nM in CV-1 cells transfected with human FXR); selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 μM; induces a 20-, 13-, and 2-fold increase in mRNA expression for IBABP, BSEP, and SHP, respectively, at a concentration of 1 μM; reduces plasma cholesterol and triglycerides and the area of pre-atherosclerotic lesions in LDLR-/- mice fed a Western diet; decreases hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis

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