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Cayman Chemical ANTIBODYR-AS-1 10mg
Supplier: Cayman Chemical 4167310 MG
A positive allosteric modulator of EAAT2 (EC50 = 11 nM in a glutamate uptake assay); selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes; increases spontaneous locomotor activity in mice at 60 and 90 mg/kg; has anticonvulsant activity in mouse models of seizures induced by MES, PTZ, or electrical stimuli of 32 or 44 mA (ED50s = 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively)
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