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Leinco Technologies Inc Anti-Human IFNγ Rα (CD119, IFNGR1, IFN-γR, IFN-γRα, IFN-α R1, CDw119) In Vivo PLATINUM; Clone GIR-208; Isotype: Mouse IgG1
Supplier: Leinco Technologies Inc G737100 MG
Specificity: Clone GIR-208 recognizes an epitope on human CD119. Antigen Distribution: IFNγ R is expressed on most cells with the exception of erythrocytes. Background: IFNγ Rα is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ R consists of α and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription. Applications: (IP, WB, B, FA) GIR-208 binds IFNGR1 and blocks binding of IFN-γ to the receptor. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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