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Enzo Life Sciences AP-18 (25mg). CAS: 55224-94-7
Supplier: Enzo Life Sciences BMLCA2390025
AP-18 is a novel TRPA1 channel blocker (CHO cells, IC50= 3.1µM; human and mouse cell lines, IC50= 4.5µM). It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs TRPV1. AP-18 was unable to block activation of TRPV1, TRPV2, TRPV3, TRPV4 or TRPM8 at concentrations up to 50μM. It reverses CFA-induced mechanical hyperalgesia in mice. Alternative name: 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25mg/ml); ethanol (25mg/ml). Long Term Storage: Ambient.
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