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Medchemexpress LLC AP-C5 | 2234272-10-5 | 98.1% | 100 MG
SDP

Supplier:  Medchemexpress LLC HY130530100MG

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AP-C5 selectively inhibits guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, making it suitable for diarrheal disease research. It is also a click chemistry reagent containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

  • Inhibits cGMP-dependent cGKII-mediated protein phosphorylation.
  • Effectively inhibits cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.
  • Potentiates cAMP signaling through PDE inhibition.
  • Partially blocks heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.

Catalog No. 50-003-40851


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