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AdipoGen AP-III-a4 HCl
Supplier: AdipoGen AGCR13696M005
Chemical. CAS 1177827-73-4 free base. Formula C31H43FN8O3 . HCl. MW 594.7 . 36.5. . Cell-permeable first non-substrate analog enolase inhibitor IC50=0.576µM. A recent study suggested no directly blocking of enolase activity in vitro and a indirect mechanism. Useful agent for immunometabolism research. The glycolysis enzymes enolase is known to have additional, non-glycolytic roles in cellular physiology, which has been termed moonlighting. Anticancer agent. Inhibits cancer cell metastasis in a zebrafish cancer cell xenograft model. Induces cell death under hypoxia and inhibits cancer cell migration and invasion by down-regulation of AKT and Bcl-xL expression. Antidiabetic agent. Reduced hyperglycemia and hyperlipidemia in mice. Reduced blood glucose, LDL cholesterol and enolase activity in T2DM mice. Had beneficial effects on lipid homeostasis, fibrosis, inflammatory markers, nephrotoxicity and cardiac hypertrophy.
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