ABclonal Technology Phospho-ErbB3/HER3-Y1328 Rabbit pAb

Supplier:  ABclonal Technology AP0277500UL

This gene encodes a member of the epidermal growth factor receptor (EGFR) family, a membrane-bound protein that binds neuregulin but lacks an active kinase domain. It does not directly convey signals but forms heterodimers with other EGFR family members that have kinase activity. Heterodimerization activates pathways leading to cell proliferation or differentiation. Amplification or overexpression of this gene is found in cancers such as prostate, bladder, and breast tumors. Alternative splicing produces isoforms, including one that lacks the intermembrane region and is secreted to modulate the membrane-bound form’s activity. Other splice variants have been reported but are not fully characterized.

Catalog No. 50-001-10686