ABclonal Technology Phospho-AKT1-T308 Rabbit pAb

Supplier:  ABclonal Technology AP03041000UL

This gene encodes a member of the AKT serine-threonine kinase family, which regulates key cellular functions such as cell proliferation, survival, metabolism, and angiogenesis. AKT proteins are activated by phosphorylation through the PI3K pathway and play a central role in signaling involving receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinases. Activation of AKT involves phosphorylation of specific residues, including threonine 308 and serine 473. AKT also participates in the mTOR pathway, which is crucial for translation initiation and often dysregulated in cancers. Mutations in this gene are linked to multiple cancers, including breast, colorectal, and ovarian, as well as conditions like Proteus and Cowden syndrome. Alternative splicing of this gene results in multiple transcript variants.

Catalog No. 50-001-13464