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ABclonal Technology AP0909-500ul Phospho-Smad2-T22
SDP

Supplier:  ABclonal Technology AP0909500UL

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This gene encodes a SMAD protein part of a family involved in signal transduction and transcriptional regulation It mediates the TGF-beta signaling pathway regulating processes like cell proliferation apoptosis and differentiation The protein is recruited to TGF-beta receptors via interaction with the SMAD anchor for receptor activation (SARA) Phosphorylation by TGF-beta receptors causes dissociation from SARA and association with SMAD4 enabling nuclear translocation In the nucleus the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase mediating activin signaling Alternative splice variants of this gene have been observed

Catalog No. 50-001-10239


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