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ABclonal Technology Phospho-PTEN-S380 Rabbit pAb
SDP

Supplier:  ABclonal Technology AP09301000UL

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This gene encodes a tumor suppressor protein that functions as a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases, but specifically dephosphorylates phosphoinositides. By regulating phosphatidylinositol-3,4,5-trisphosphate levels, it negatively controls the AKT/PKB signaling pathway. A non-canonical upstream initiation site produces a longer isoform associated with the mitochondrial inner membrane, potentially involved in energy metabolism regulation. A pseudogene of this gene is located on chromosome 9. Alternative splicing and multiple translation start sites result in various isoforms.

Catalog No. 50-001-12080


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