ABclonal Technology Phospho-IGF-IReceptorβ(Tyr1135/1136)/InsulinReceptorβ(Tyr1150/1151) Rabbit pAb

Supplier:  ABclonal Technology AP1352500UL

This gene encodes a member of the receptor tyrosine kinase family. The preproprotein is processed into alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands activates the insulin signaling pathway, regulating glucose uptake, release, and the synthesis and storage of carbohydrates, lipids, and proteins. Mutations in this gene cause inherited severe insulin resistance syndromes, such as type A insulin resistance syndrome, Donohue syndrome, and Rabson-Mendenhall syndrome. The receptor also binds insulin-like growth factor and has tyrosine kinase activity. It plays a critical role in transformation events and is overexpressed in malignant tissues, acting as an anti-apoptotic agent. Alternative splicing produces multiple transcript variants encoding distinct isoforms.

Catalog No. 50-001-12169