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ABclonal Technology AP1429-20ul ATF-2 Thr69/71/ATF
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Supplier:  ABclonal Technology AP142920UL

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This gene encodes a transcription factor from the leucine zipper family which binds to the cAMP-responsive element (CRE) and stimulates CRE-dependent transcription The protein functions as a histone acetyltransferase (HAT) acetylating histones H2B and H4 thus activating transcription by modifying chromatin It also plays a role in the DNA damage response independent of transcriptional regulation The protein has DNA-binding transcription repressor activity RNA polymerase II-specific activity and binds to transcription coactivators It negatively and positively regulates RNA polymerase II-dependent transcription The protein is located in the nucleoplasm and is a biomarker for colorectal cancer Several alternatively spliced transcript variants have been identified for this gene

Catalog No. 50-001-11197


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