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Medchemexpress LLC Apabetalone | 1044870-39-4 | 99.34% | 370.40 | 100 MG
Supplier: Medchemexpress LLC HY16652100MG
Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators, specifically targeting the second bromodomain (BD2) with high selectivity. It enhances the production of ApoA-I in hepatocytes, leading to an increase in high-density lipoprotein cholesterol (HDL-C). Its mechanism involves binding to bromodomains of the BET family by competing for acetylated lysine binding sites. This epigenetic modulation of ApoA-I production suggests it as a potential therapeutic agent for atherosclerosis.
- Selective BET transcriptional regulator inhibitor
- Targets the second bromodomain (BD2)
- Increases ApoA-I production in liver cells
- Elevates high-density lipoprotein cholesterol (HDL-C)
- Acts via an epigenetic mechanism
- Investigated for atherosclerosis treatment
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