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AdipoGen Apaf-1 mAb 18H2
SDP

Supplier:  AdipoGen AG20T0134C100

Encompass_Preferred

Monoclonal Antibody. Recognizes the CARD domain of human and mouse Apaf-1. Does not cross-react with rat Apaf-1. Isotype Rat IgG2akappa. Clone 18H2. Applications ELISA, ICC, IP, WB. Liquid. In PBS containing 0.02% sodium azide. Apaf-1 is a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. It contains from the N terminal a caspase recruitment domain CARD, an ATPase domain NB-ARC, few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome, mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 Apaf-3, leading to the activation of caspase-3 and apoptosis.

Catalog No. 50-256-3345


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