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Cayman Chemical Apamin trifluoroacetate salt
Supplier: Cayman Chemical 17082500 UG
An inhibitor of KCa2.2/SK2 channels (IC50s = 0.06-0.4 nM); selective for KCa2.2/SK2 channels over KCa2.1/SK1 and KCa2.3/SK3 channels (IC50s = 1-12 and 1-13 nM, respectively), as well as KCa3.1/SK4 channels at 1 µM but does inhibit Kv1.3 (IC50 = 13 nM); reduces CD8+ cell infiltration into the CNS and EAE severity, as well as increases peripheral blood levels of CD62L-, CD44L-, and CD44+ memory T cells, in mice; has commonly been used to determine the role of KCa/SK channels in various cells and tissues
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