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Cayman Chemical Apararenon 10mg
Supplier: Cayman Chemical 3067110 MG
A non-steroidal mineralocorticoid receptor antagonist (Ki = 0.104 µM for the human receptor); selective for mineralocorticoid receptors over ERα and ERβ and glucocorticoid, progesterone, and androgen receptors (IC50s = >100 µM for all); increases the urinary ratio of sodium to potassium in adrenalectomized rats; inhibits aldosterone- and nephrectomy-induced increases in systolic blood pressure and urinary albumin levels, as well as myocardial necrosis and fibrosis, cardiac arterial degeneration, and renal tubule damage, in a rat model of renal hypertension at 3 or 10 mg/kg per day
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