ABclonal Technology APC anti-Human CD162/PSGL-1

Supplier:  ABclonal Technology A25494500T

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P- E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes As such this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins This protein requires two post-translational modifications tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans for its high-affinity binding activity Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response Alternate splicing results in multiple transcript variants

Catalog No. 50-000-11220