ABclonal Technology APC Rabbit anti-Human mGluR2

Supplier:  ABclonal Technology A27131500T

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology putative signal transduction mechanisms and pharmacologic properties Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C Group II includes GRM2 and GRM3 while Group III includes GRM4 GRM6 GRM7 and GRM8 Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities Several transcript variants encoding different isoforms have been found for this gene

Catalog No. 50-000-12220