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Medchemexpress LLC Aphidicolin | 38966-21-1 | 10 MG
SDP

Catalog No. 5000418005
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Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.

  • Inhibits DNA polymerase α and δ.
  • Functions as an antibiotic from *Cephalosporium aphidicola*.
  • Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
  • Modulates cell cycle, arresting cells at G2 phase.
  • Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
  • Aphidicolin glycinate demonstrates anti-tumor activity in murine models.

Catalog No. 50-004-18005 Supplier Medchemexpress LLC Supplier No. HYN673310MG
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Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.

  • Inhibits DNA polymerase α and δ.
  • Functions as an antibiotic from *Cephalosporium aphidicola*.
  • Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
  • Modulates cell cycle, arresting cells at G2 phase.
  • Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
  • Aphidicolin glycinate demonstrates anti-tumor activity in murine models.

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