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Medchemexpress LLC Aphidicolin | 38966-21-1 | 10 MG
Supplier: Medchemexpress LLC HYN673310MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.
- Inhibits DNA polymerase α and δ.
- Functions as an antibiotic from *Cephalosporium aphidicola*.
- Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
- Modulates cell cycle, arresting cells at G2 phase.
- Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
- Aphidicolin glycinate demonstrates anti-tumor activity in murine models.
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