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Medchemexpress LLC Aphidicolin | 38966-21-1 | 5 MG
Supplier: Medchemexpress LLC HYN67335MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. It also demonstrates anti-orthopoxvirus activity and enhances apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Antibiotic from Cephalosporium aphidicola
- Inhibits DNA synthesis and herpes simplex virus growth
- Exhibits anti-orthopoxvirus activity
- Enhances apoptosis
- Selectively kills neuroblastoma cells
- Arrests cell cycle at G2 phase
- Inhibits cell proliferation via p53-GADD45β pathway
- Inhibits Varicella-zoster virus (VZV)
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