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Medchemexpress LLC Apigenin | 520-36-5 | 270.24 | 1 G
Supplier: Medchemexpress LLC HYN12011G
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor that inhibits cytochrome P450 2C9 in a purified enzyme system. It demonstrates dose- and time-dependent inhibition of cell proliferation in SGC-7901 cells.
- Competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Inhibits cytochrome P450 2C9 in a purified, reconstituted enzyme system.
- Demonstrates inhibition of cell proliferation in SGC-7901 cells in a dose- and time-dependent manner.
- Achieves growth inhibition rates of 38%, 71%, and 99% at 20, 40, and 80 μM, respectively, on the 7th day.
- Cloning efficiency in SGC-7901 cells treated with 80 μM for 24 and 48 hours was 9.8% and 5%, respectively.
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