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Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG
Supplier: Medchemexpress LLC HY14644200MG
Apilimod is a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is also described as a potent and highly selective PIKfyve inhibitor.
- Potent IL-12/IL-23 inhibitor
- Strongly inhibits IL-12 with IC50s of 1 nM and 2 nM
- Potent and highly selective PIKfyve inhibitor
- Inhibits IFN-γ production in human PBMCs
- Reduces severity of experimental autoimmune uveoretinitis (EAU)
- Lowers level of IL-12 p40 in serum without altering body weight in EAU mice
- Effective in Th1 model, with 51%±8% inhibition
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