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ABclonal Technology Apolipoprotein A1/APOA1
Supplier: ABclonal Technology A2429020UL
This gene encodes apolipoprotein A-I which is the major protein component of high density lipoprotein (HDL) in plasma The encoded preproprotein is proteolytically processed to generate the mature protein which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT) an enzyme responsible for the formation of most plasma cholesteryl esters This gene is closely linked with two other apolipoprotein genes on chromosome 11 Defects in this gene are associated with HDL deficiencies including Tangier disease and with systemic non-neuropathic amyloidosis Alternative splicing results in multiple transcript variants at least one of which encodes a preproprotein
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