Apramycin sulfate

Description

Apramycin sulfate, CAS # 65710-07-8, is the salt of apramycin, the bacteriostatic aminoglycoside antibiotic. | CAS: 65710-07-8 | C21H43N5O15S | 637.66 g/mol

Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Apramycin is a 2-deoxysteptamine derivative and an aminoglycoside originally isolated from Streptomyces tenebrarius
• Apramycin sulfate is comprised of a bicyclic sugar moiety and a monosubstituted deoxystreptamine attached to a sulfate group

Application

• Apramycin sulfate exhibits antibiotic activity against gram-negative bacteria
• It is suitable for laboratory use against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa
• It is also used for laboratory study of infectious disease

Specifications

Chemical Identifiers

• CAS: 65710-07-8
• Molecular Formula: C21H43N5O15S
• Molecular Weight (g/mol): 637.66
• MDL Number: MFCD06200257
• InChI Key: WGLYHYWDYPSNPF-RQFIXDHTSA-N
• Synonym: Nebramycin II
• PubChem CID: 3081544
• IUPAC Name: (2R,3R,4S,5S,6S)-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)-octahydropyrano[3,2-b]pyran-2-yl]oxy}-5-amino-6-(hydroxymethyl)oxane-3,4-diol; sulfuric acid
• SMILES: OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]1O[C@H](CO)[C@@H](N)[C@H](O)[C@H]1O

• Type: Apramycin Sulfate
• Physical Form: Powder
• Melting Point: 168°C
• Color: Yellow
• Quantity: 10 g
• Flash Point: >110°C (230°F)
• Boiling Point: 823°C
• Solubility Information: Soluble in water at 25mg/ml
• Formula Weight: 637.65
• Chemical Name or Material: Apramycin sulfate

Safety and Handling

Hazard Category	H315-H319-H360
Hazard Statement	H360-H315-H319; May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P201-P202-P264b-P280i-P281-P302+P352-P305+P351+P338-P308+P313-P332+P313-P362-P501c
EINECSNumber	265-890-7
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only