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Apexbio Technology LLC Apremilast (CC-10004) 608141-41-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43175.1
Apremilast (CC-10004 CAS 608141-41-9) is a small-molecule inhibitor of phosphodiesterase 4 (PDE4) an enzyme involved in cyclic adenosine monophosphate (cAMP) hydrolysis and cytokine signaling pathways By competitively binding PDE4 s catalytic domain apremilast prevents intracellular cAMP degradation (IC50 0 074 M Ki 68 nM) thereby suppressing production of inflammatory mediators such as tumor necrosis factor- interleukin-23 CXCL9 and CXCL10 Due to these anti-inflammatory effects apremilast serves as a significant research tool in autoimmune conditions notably psoriasis and psoriatic arthritis
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