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AdipoGen APRIL (human) (multimeric) (rec.) (10 µg)
Supplier: AdipoGen AG40B0017C010
Protein. The extracellular domain of human APRIL (aa 88-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse BCMA and TACI. Binds to proteoglycans. Purity: >95% (SDS-PAGE). APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30 effectively stimulating proliferation of B cells. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to proteoglycans.
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