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AdipoGen APRIL (mouse) (H98) (multimeric) (rec.) (3 x 10 µg)
SDP

Supplier:  AdipoGen AG40B00353010

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Protein. The extracellular domain of mouse APRIL (aa 98-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS + 0.5% Trehalose. Binds to human and mouse BCMA and TACI. Does not bind to proteoglycans. Purity: >95% (SDS-PAGE). APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

Catalog No. 50-205-3107


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