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AdipoGen APRIL ms mAb Centotto-1
Supplier: AdipoGen AG20B0083PFC500
Monoclonal Antibody. Recognizes mouse recombinant and endogenous APRIL. Applications FUNC Blocking, IP. Clone Centotto-1. Isotype Mouse IgG1kappa. Liquid. In PBS. APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor TACI, B cell maturation antigen BCMA and can interact with carbohydrate side chains of heparan sulfate proteoglycans HSPG that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL as well as BAFF stimulates class-switch recombination CSR, hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell LLPC pool in the bone marrow BM.
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