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Cayman Chemical Apum lptopylum Bgaptn 100mg
Supplier: Cayman Chemical 26254100 MG
A furanocoumarin derivative with diverse biological activities; decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis at 50 μM; has photosensitizing activity; increases the number of sunburn cells in guinea pig skin in response to UVA radiation; increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain at 10 mg/kg; inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in GSH levels in the spinal cord and sciatic nerve in rats; inhibits CYP3A4 (IC50 = ~25 μM) in human liver microsomes
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