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Cayman Chemical aPyroldInobutIothIophenon 50mg

Supplier: Cayman Chemical 1535850 MG

A PI3KY inhibitor (IC50 0.025 UM in a binding assay) selective for PI3KY over PI3K PI3Ka and PI3KB (IC50s 7.9 10 and 1.26 UM respectively in binding assays) as well as a panel of 154 lipid and protein kinases inhibits C5a-induced phosphorylation of Akt in RAW 264.7 macrophages (IC50 1.2 UM) inhibits fMLP-induced migration of isolated human granulocytes (IC50 1 UM) decreases disease severity in a mouse model of collagen-induced arthritis at 3 and 10 mg/kg
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