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Cayman Chemical ArachIdonyl thIo-PC 10mg

Supplier: Cayman Chemical 6224010 MG

A KAT6A and KAT7 inhibitor (IC50s 17 and 30 nM respectively) selective for KAT6A and KAT7 over KAT5 (IC50 312 nM) reduces the viability of primary mouse LSCs MOLM-13 and OCI-AML-3 AML cells as well as decreases colony formation in patient-derived primary AML cells at 1 UM induces cell cycle arrest at the sub-G1 phase and apoptosis as well as decreases the levels of mRNA encoding HOXA7 in MOLM-13 cells at 1 UM reduces tumor volume weight and growth rate as well as decreases the acetylation at H3K14 H3K12 and H3K5 in tumor cell lysates in a PPC-1 prostate cancer mouse xenograft model
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