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Medchemexpress LLC ARD-2051 | 2632305-17-8 | 98.6% | 789.32 | 50 MG
Supplier: Medchemexpress LLC HY14986250MG
ARD-2051 is a selective and orally active proteolysis-targeting chimera (PROTAC) degrader targeting the androgen receptor (AR). It effectively degrades AR protein with DC50 values of 0.6 nM in prostate cancer cell lines (LNCaP and VCaP) and shows significant anti-tumor activity in VCaP xenograft mouse models, making it suitable for prostate cancer research.
- Selective and orally active PROTAC degrader
- Targets the androgen receptor (AR)
- Induces AR protein degradation (DC50 of 0.6 nM in LNCaP and VCaP cells)
- Inhibits cell growth (IC50 of 12.8 nM in LNCaP, 10.2 nM in VCaP)
- Suppresses expression of the AR-regulated gene KLK3
- Demonstrates anti-tumor activity in VCaP xenograft mice models
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