Medchemexpress LLC ARD-2585 | 2757422-79-8 | 98.2% | 763.28 | 1 MG

Supplier:  Medchemexpress LLC HY1394361MG

ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor. It achieves DC50 values of 0.04-0.1 nM in the VCaP cell line with AR gene amplification and in the LNCaP cell line carrying an AR mutation. ARD-2585 (100 nM) is effective in reducing the AR protein level at the 3 and 24 hour time-points by 78% (p < 0.01) and 60% at the 6 hour time-point (p > 0.05).

• Achieves DC50 values of 0.04-0.1 nM in VCaP and LNCaP cell lines.
• Reduces AR protein level by 78% at 3 and 24 hour time-points (100 nM).
• Exhibits antiproliferative activity against human LNCaP cells (IC50: 16.2 nM).
• Exhibits antiproliferative activity against human VCaP cells (IC50: 1.5 nM).

Catalog No. 50-003-50156