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Cayman Chemical ArenobufagIn 10mg
Supplier: Cayman Chemical 3069510 MG
A cardiotonic steroid with anticancer activity; inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes (IC50 = 290 nM); increases cleavage of PARP, caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells; It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively); reduces tumor growth, the number and size of lung metastases, and tumor levels of the EMT markers vimentin and β-catenin in a PC3 mouse xenograft model at 1 mg/kg; inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice at 5 and 10 µM/plug
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