AdipoGen Arginase I h highly active

Supplier:  AdipoGen AG40T0124C010

Protein. Full length human arginase I. Source E. coli. Liquid. In 10mM TRIS-HCl, pH 7.5, containing 1mM beta-mercaptoethanol, 1mM MnCl2 and 50% glycerol. Purity >90% SDS-PAGE. Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist types I and II which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide NO pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.

Catalog No. 50-256-2755