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Apexbio Technology LLC Aripiprazole 129722-12-9 1g
Supplier: Apexbio Technology LLC B22321000
Aripiprazole (CAS 129722-12-9) is a non-typical antipsychotic compound characterized as a dopamine-serotonin system stabilizer It acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and exhibits antagonist properties at 5-HT2A receptors Binding studies indicate high affinity to D2 receptors with reported Kd values of 0 34 0 02 nM (agonist radioligand [125I]7-OH-PIPAT) and 0 70 0 22 nM (antagonist [3H]spiperone) In cellular assays aripiprazole inhibits forskolin-induced cAMP accumulation in CHO and HEK-293 cells and suppresses quinpirole-stimulated GTPase activity in rat striatal membranes These properties position aripiprazole as a valuable tool for investigating dopaminergic and serotonergic signaling pathways
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