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Cayman Chemical ARK1 InhIbItr 5mg
Supplier: Cayman Chemical 217515 MG
An inhibitor of GRK2/βARK1 (IC50 = 126 µM); selective for GRK2/βARK1 over PKA at concentrations up to 1 mM; decreases systolic blood pressure in ob/ob and nicotinamide plus streptozotocin-induced mouse models of type 2 diabetes at 200 UG/kg; improves clonidine-induced relaxation of precontracted isolated aortic rings and improves glucose tolerance in the ob/ob mouse model; inhibits serotonin- or neurotensin-induced DIR in the rat ventral tegmental area in vitro
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